Gastroenterologist Sonia Kupfer, MD, and genetic counselor Jessica Stoll, MS, CGC
Gastroenterologist Sonia Kupfer, MD, left, and genetic counselor Jessica Stoll, MS, CGC, are experts in gastrointestinal cancer risk assessment.

The Gastrointestinal Cancer Risk and Prevention Clinic at the University of Chicago Medicine offers personalized risk assessment for patients and families who may be at increased risk for developing gastrointestinal malignancies — such as colorectal, gastric or pancreatic cancers — due to genetic factors. Our services include:

  • Gastrointestinal cancer risk assessment and genetic testing
  • Cancer prevention counseling and strategies
  • Colorectal cancer screening and surveillance, including colonoscopy
  • Pancreatic cancer screening for high-risk patients
  • Gastrointestinal surgical procedures
  • Cancer prevention in patients with inflammatory bowel disease (e.g. Crohn’s disease or ulcerative colitis)

Evaluation and risk assessment are offered for individuals who have the following medical history:

  • Multiple gastrointestinal polyps
  • Inflammatory bowel disease, especially with longstanding colon involvement
  • Colorectal cancer before the age of 50
  • Colorectal cancer at any age with a personal or family history of other cancers
  • Pancreatic cancer at any age with a personal or family history of other cancers
  • Gastric adenocarcinoma before the age of 50 and/or personal or family history of breast cancer 

Evaluation and risk assessment are recommended for families who have a genetic mutation associated with any of the following cancer predisposition syndromes:

  • Lynch syndrome, also called HNPCC (hereditary non-polyposis colorectal cancer)
  • Familial adenomatous polyposis (FAP)
  • Juvenile polyposis syndrome
  • Peutz-Jeghers syndrome

Can you inherit gastrointestinal cancer?

In some instances, GI cancer runs in families and the risk of getting cancer is passed down from generation to generation. Gastroenterologist Sonia Kupfer, MD, answers frequently asked questions about gastrointestinal cancer risk and prevention.

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Meet Our Gastrointestinal Cancer Risk & Prevention Physician Team

Free Event: Spotlight on Stomach Cancer

Join UChicago Medicine and No Stomach for Cancer for Spotlight on Stomach Cancer, a free event about hereditary stomach cancer for the general public, patients and caregivers.



June 1, 2019, 8 a.m. to 2 p.m., followed by a reception and live music



UChicago Medicine Campus
900 E. 57th Street, KCBD Auditorium 1103
Chicago, IL, 60637

Medical oncologist Jane Churpek, MD, and gastroenterologist Sonia Kupfer, MD

Assessing Your Risk for Cancer

researcher in cancer lab

Participate in a Clinical Trial