UChicago Medicine Comprehensive Cancer Center

In some cases, an inherited syndrome contributes to an increased risk of developing stomach cancer, also known as gastric cancer. Hereditary diffuse gastric cancer (HDGC) syndrome significantly increases the risk for diffuse gastric cancer, as well as lobular breast cancer. Carrying a mutation in the CDH1 gene raises the risk of diffuse gastric cancer as much as 70% for men and 56% for women, compared to a <1% chance in people without a CDH1 mutation.


Feighanne Hathaway, genetic counselor

GI Cancer Risk and Prevention

The Gastrointestinal Cancer Risk and Prevention Clinic cares for individuals who have an increased risk of gastrointestinal cancer due to family history, medical and genetic factors, and more.

Learn about GI cancer risk and prevention
Medical oncologist Kenneth Cohen, MD, pointing to a computer and talking with a patient

Cancer Care Second Opinions

Request a second opinion from UChicago Medicine experts in cancer care.

researcher in cancer lab

Participate in a Clinical Trial

Find a stomach cancer clinical trial at UChicago Medicine.

Vivek Prachand, MD, and team in surgery

Why Choose Us for Cancer Surgery?

Our surgeons offer sophisticated techniques, including minimally invasive and robotic options, to treat cancer.