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Cardiology (Heart Care), Transplant | More

Assistant Professor of Medicine Director, Mechanical Circulatory Support

A clinically integrated network of physicians and providers employed by UChicago Medicine who offer care in inpatient, community, ambulatory, acute care or extended care settings.


Jonathan Grinstein, MD, FACC, is a highly respected cardiologist specializing in the medical management of advanced heart failure. Dr. Grinstein treats patients who require long-term IV medications or continuous infusion pump medications, mechanical circulatory support, such as left ventricular assist devices (LVADs), and heart transplantation.

Along with his devotion to excellent clinical care, Dr. Grinstein is passionate about furthering medicine through research. Dr. Grinstein has evaluated and perfected echocardiographic and computed tomography techniques that noninvasively monitor the pressure and volume inside the heart for patients with an implanted LVAD. This technique allows cardiologists to analyze how well a patient is responding to the device and make necessary adjustments in real time. Additionally, Dr. Grinstein is conducting research to develop a “smart” LVAD that can intuitively adjust its speed based on the physiological needs of the patient. He is also using computational fluid dynamics to study and predict blood flow patterns through the LVAD to maximize device performance.

Dr. Grinstein’s research has been published in several high-impact, peer-reviewed journals, including the Journal of Cardiac Failure, American Society for Artificial Internal Organs Journal, Journal of Heart and Lung Transplantation and JACC: Cardiovascular Imaging.

Medical Education

  • University of Chicago Pritzker School of Medicine


  • Brigham and Women's Hospital


  • Brigham and Women's Hospital


  • University of Chicago Medicine

Memberships & Medical Societies

  • International Society for Heart and Lung Transplantation
  • American College of Cardiology
  • Heart Failure Society of America
  • Alpha Omega Alpha Honor Medical Society
  • Gold Humanism Honor Society
  • Aetna POS
  • Aetna HMO
  • Aetna PPO
  • BCBS Blue Precision HMO
  • Cigna HMO
  • Cigna POS
  • Cigna PPO
  • CountyCare
  • Coventry Health Plan PPO
  • Great West PPO
  • Illinicare*
  • Medicare
  • Multiplan PPO
  • United Choice / Choice Plus
  • United Options (PPO)
  • United Select (HMO & EPO)
  • United W500 Emergent Wrap
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Duchossois Center for Advanced Medicine (DCAM) - Hyde Park

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At a Glance

Board Certifications

  • Advanced Heart Failure
  • Cardiovascular Disease
  • Internal Medicine

Languages Spoken

  • English