At the Forefront - UChicago Medicine

Treatment-Resistant Disorders

Care for Treatment-Resistant Disorders

Treatment-Resistant Mood Disorders Program

Our treatment-resistant mood disorders program offers comprehensive evaluation and therapies for those who have not responded to more than one preceding trial of antidepressants and/or mood stabilizers. Patients referred for electroconvulsive therapy (ECT) generally fit in this category.

Therapies include:

  • Cognitive behavioral therapy
  • Deep-brain stimulation
  • ECT
  • Medication management
  • Esketamine (Spravato): A prescription nasal spray medication used to treat treatment-resistant depression (TRD) in adults

Refractory Psychosis Program

Our refractory psychosis program provides consultation to individuals and programs seeking recommendations for management and treatment of psychotic disorders, such as schizophrenia and schizoaffective disorders that have been resistant to treatment.

The program also offers ongoing medication management for patients with psychotic disorders who do not need a system of care to provide psychosocial rehabilitation. Diagnostic procedures, such as neuropsychological testing, brain imaging and blood tests, may be part of the evaluation.

No-Cost, Confidential Assessment & Referrals

In order to quickly respond to your needs, a trained mental health professional is available 24 hours a day, 7 days a week.

You can make an appointment by calling:

Our assessment and referral staff assess each individual to determine his or her behavioral health needs and makes referrals based on those needs.

Our Treatment-Resistant Disorder Locations

Request an Appointment

We are currently experiencing a high volume of inquiries, leading to delayed response times. For faster assistance, please call 1-888-824-0200 to schedule your appointment.

If you have symptoms of an urgent nature, please call your doctor or go to the emergency room immediately.

By submitting this form you acknowledge the risk of sending this information by email and agree not to hold the University of Chicago or University of Chicago Medical Center liable for any damages you may incur as a result of the transfer or use of this information. The use or transmittal of this form does not create a physician-contact relationship. More information regarding the confidentiality of this request can be found in our Privacy Policy.

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By submitting this form you acknowledge the risk of sending this information by email and agree not to hold the University of Chicago or University of Chicago Medical Center liable for any damages you may incur as a result of the transfer or use of this information. The use or transmittal of this form does not create a physician-contact relationship. More information regarding the confidentiality of this request can be found in our Privacy Policy.