Total pancreatectomy with islet autotransplantation has emerged as a surgical option for treating patients with debilitating pain from chronic pancreatitis. It may also be an option for patients with recurrent acute pancreatitis, who experience multiple hospitalizations that affect their quality of life, including their ability to work or go to school.

Dr. Jeffrey B. Matthews, Dallas B. Phemister Professor of Surgery and Chair of the Department of Surgery, and Dr. Piotr Witkowski, Assistant Professor of Surgery and Director of the Pancreatic and Islet Transplant Program
Dr. Jeffrey B. Matthews and Dr. Piotr Witkowski

About 70 percent of patients experience dramatic pain relief after total pancreatectomy (TP) with autologous islet cell transplantation (IAT). Approximately 30 to 40 percent of patients who have IAT will not require insulin injections after the procedure. Other patients may need to take daily insulin and monitor their blood glucose closely, but the severity of their diabetes is less compared to patients who did not undergo IAT.

The University of Chicago Medicine is one of a few U.S. hospitals to offer autologous islet cell transplantation after total pancreatectomy. The goal is to prevent the onset of diabetes or reduce the severity of the disease.

Breakthrough Pancreatic Research & Clinical Trials

As a top research institution, UChicago Medicine offers qualified patients the unique opportunity to advance biomedical innovation by participating in structured clinical studies. Our physicians currently are examining the safety and efficacy of a drug aimed at reducing the risk of diabetes development in patients undergoing total pancreatectomy with islet autotransplantation for chronic pancreatitis.

Find out if you are eligible to participate in a clinical trial 

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