Pancreas & Islet Transplant

Pancreas & Islet Transplant

Dr. Hasan with diabetes patient in an exam room

Leading Diabetes Treatment & Research for 100 Years

Breakthroughs made at the University of Chicago Medicine have shaped today's treatment of diabetes. Notably, one of our researchers played a crucial role in the discovery of insulin — an event that has saved countless lives of people with Type 1 diabetes. More recently, we were the first hospital in Illinois to perform a pancreas transplant for a patient with advanced diabetes. Currently, we are also testing another exciting, but experimental, treatment for Type 1 diabetes known as islet transplantation.

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Pancreas Transplant for Advanced Diabetes

When Type 1 diabetes cannot be controlled or is causing serious problems, a patient may want to think about a pancreas transplant. For patients with severe Type 1 diabetes, a pancreas transplant offers the greatest chance of a lifestyle free of insulin shots.

Pancreas-Only Transplant

This procedure is for people with Type 1 diabetes who have healthy kidney function or who already have a functioning kidney transplant. Nearly all patients who receive a pancreas from a deceased donor no longer need insulin shots. Their risk for kidney disease and other diabetic complications may also be lower after a transplant.

Kidney-Pancreas Transplant

Patients who have Type 1 diabetes and significant kidney disease may require a combined kidney and pancreas transplant. Their kidney and pancreas are from the same deceased donor and are transplanted during the same operation. For many diabetics with kidney failure, this procedure provides the greatest hope for a life without dialysis or insulin injections.

Outcomes

Success rates for both of these transplant operations are high. Patients who remain free of rejection for the first year have a high likelihood of keeping their organ for one or more decades. We consult one-on-one with patients and their families to determine the best option: pancreas-only or combined pancreas-kidney transplant.

Patient Mark Morrison with surgeon Piotr Witkowski, MD, Assistant Professor of Transplant Surgery and Director, Pancreatic and Islet Transplant Program, and transplant nurse
Transplant nurse with surgeon Piotr Witkowski, MD, Director of the Pancreatic and Islet Transplant Program
Patient Mark Morrison with surgeon Piotr Witkowski, MD, Director of the Pancreatic and Islet Transplant Program,
Group photo during the Islet transplant reunion at the Center for Care and Discovery on the University of Chicago campus in Chicago, Ill., on Sunday, June 28, 2015

Compassionate & Accessible Team of Providers

Photo of members of the Pancreas Center Team, Jeffrey Matthews, MD, Chair of the Department of Surgery, and Piotr Wikowski, MD, PhdD, Assistant Professor of Surgery and the Director of Pancreatic and Islet Transplant Program
Meet Our Team

We pride ourselves on being available at all times to patients. The entire team works exclusively with transplant patients, allowing us to offer tailored treatment and unmatched expertise.

Diabetic patient receiving dialysis at Orland Park
The Pancreas Transplant Process

During the months before and after transplant surgery, each patient is assigned a transplant coordinator. She or he is your personal advocate and is available by phone or page any time of the day or night.

Islet Transplant Clinical Trials for Diabetes

We are among a select number of hospitals in the country testing the effectiveness of islet transplants. Islet transplants are intended to treat advanced Type 1 diabetes by replacing destroyed islets with new ones. The islet cells from a deceased donor's pancreas are removed and injected into a patient's liver so they may begin to make insulin. No surgery is needed. Though promising, we still don't know the long-term benefits and risks of this procedure, which is why we are active in multiple clinical trials.

Patient Stories

Islet transplant patient, Luke Clouser, warming up at soccer practice
Mark Morrison, islet transplant patient, with his physician, Piotr Witkowski, MD
Joey Knoop poses for a photo

Transplant Articles

Liver donor liver transplant infographic
How living donor liver transplant works
Woman hugging a transplant patient
Finding a living donor when you need an organ transplant
Insulin-free islet transplant recipient Mark Morrison visits his doctors
Patients with diabetes insulin-free for years after islet transplantation
fatty liver risk
Are you at risk for fatty liver disease?
model of a liver
The most common chronic liver condition: What is fatty liver disease and how is it treated?
Angelica Perez-Gutierrez, MD
Despite the pandemic, UChicago Medicine performed a record number of transplants in 2021, mirroring a nationwide trend
Patient with pulmonary fibrosis
Interstitial Lung Disease Clinic provides specialized care for patients with chronic lung diseases
Heart transplant patient Lane Jenkins
California man travels to UChicago Medicine for life-saving bloodless heart transplant from the nation’s most experienced team
UChicago campus hero
New data: UChicago Medicine’s Heart Transplant Program earns country’s highest marks for success