Stem cell transplant is being used to treat many types of conditions and can often be used when conventional treatments have been unsuccessful. Stem cell transplantation is an emerging first-line therapy for some serious diseases, including:
- Hematologic malignancies and leukemias particularly:
- Acute lymphoblastic leukemia (ALL)
- Acute myelogenous leukemia (AML)
- Chronic myelogenous leukemia (CML)
- Juvenile myelomonocytic leukemias (JMML/CMML)
- Myelodysplastic syndromes (MDS)
- Secondary leukemias
- Relapsed/refractory leukemia that has failed other therapies
- Hodgkin and Non-Hodgkin lymphoma
- Neuroblastoma
- Sarcomas
- Other solid tumors of childhood
- Hemophagocytic lymphohistiocytosis (HLH)
- Hemoglobinopathies including sickle cell anemia and β-thalassemia
- Aplastic anemia
- Fanconi anemia
- Rare blood diseases including chronic granulomatous disease, Chediak-Higashi and Schwachman-Diamond syndromes, and dyskeratosis congenital disease
- Paroxysmal nocturnal hemoglobinuria
- Bone marrow failure syndromes
- Metabolic/lysosomal storage diseases
- Immunodeficiencies including severe combined immunodeficiency (SCID) and Wiskott-Aldrich Syndrome
- Autoimmune conditions including systemic lupus erythematosus (SLE), rheumatoid arthritis and scleroderma
