One of Dr. Mastrianni's research projects, funded by a $1.5 million National Institutes of Health (NIH) grant, focuses on understanding animal and human prion diseases, which are progressive and infectious neurodegenerative disorders, such as mad cow disease and Creutzfeldt-Jakob disease. Prion diseases share many similarities with more common neurodegenerative conditions, such as Alzheimer's disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS). Therefore, Dr. Mastrianni’s studies aimed at understanding and correcting the underlying defect in prion diseases may likely help researchers to better understand these more common diseases, as well.
In another collaborative study, Dr. Mastrianni uses cognitive screening assessments combined with advanced brain imaging to predict whether individuals with mild memory problems will develop Alzheimer’s disease in the future.
An accomplished author, Dr. Mastrianni has published more than 40 scientific articles, as well as several book chapters and reviews. He is an invited contributor for Neurology, Journal Watch Neurology, Genetics in Medicine, Trends in Molecular Medicine, and other prestigious medical journals. Dr. Mastrianni is the recipient of many awards and honors. Recently, he was named the Helen M. McLoraine Neuroscience Investigator of the Brain Research Foundation and was appointed as an expert reviewer for the ECRI Institute of the U.S. Agency for Health Care Research and Quality. He has been reappointed to a neuroscience advisory committee of the U.S. Food and Drug Administrations (FDA). Also a dedicated educator, Dr. Mastrianni teaches and mentors students, residents, and doctoral and post-doctoral students.
Specialties
Areas of Expertise
Board Certifications
- Neurology
- Psychiatry
Memberships & Medical Societies
- Sigma Xi
- American Academy of Neurology
- American Association for the Advancement of Science
- American Neurological Association
- New York Academy of Sciences
- Society for Neuroscience
- World Federation of Neurology
Practicing Since
- 1989
Languages Spoken
- English
Medical Education
- McGill University Faculty of Medicine
Internship
- Hospitals of the University of Pennsylvania
Residency
- Hospitals of the University of Pennsylvania
Fellowship
- McGill University Faculty of Medicine; Howard Hughes Medical Institute; National Institute of Alcohol, Abuse and Alcoholism
Other Grad Education
- PhD, University of North Carolina
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