UChicago Faculty Physician
James Mastrianni, MD, PhD
James Mastrianni, MD, PhD
UChicago Faculty Physician
Professor of Neurology
Professor of Neuroscience Institute
Co-Director, Center for Comprehensive Care and Research on Memory Disorders
Director, Memory Center
Specialties
- Neurology
Locations
- Chicago - South Shore
- Chicago - Hyde Park
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- About
- Specialties & Areas of Expertise
- Locations & Patient Information
- Education & Research
- Accepted Insurance
James Mastrianni, MD, PhD, is an expert in memory disorders and other neurodegenerative conditions. Working on a team of geriatricians, neurologists and neuropsychologists, Dr. Mastrianni provides diagnostic evaluation and long-term management of patients with Alzheimer's disease and related dementias. In a special clinic, he also evaluates patients referred to him with atypical dementias, which are unusual dementias for which a clear diagnosis cannot yet be determined. In addition to providing effective care for these patients, Dr. Mastrianni and his colleagues conduct clinical and basic science research to better understand and treat neurodegenerative diseases.
One of Dr. Mastrianni's research projects, funded by a $1.5 million National Institutes of Health (NIH) grant, focuses on understanding animal and human prion diseases, which are progressive and infectious neurodegenerative disorders, such as mad cow disease and Creutzfeldt-Jakob disease. Prion diseases share many similarities with more common neurodegenerative conditions, such as Alzheimer's disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS). Therefore, Dr. Mastrianni’s studies aimed at understanding and correcting the underlying defect in prion diseases may likely help researchers to better understand these more common diseases, as well.
In another collaborative study, Dr. Mastrianni uses cognitive screening assessments combined with advanced brain imaging to predict whether individuals with mild memory problems will develop Alzheimer’s disease in the future.
An accomplished author, Dr. Mastrianni has published more than 40 scientific articles, as well as several book chapters and reviews. He is an invited contributor for Neurology, Journal Watch Neurology, Genetics in Medicine, Trends in Molecular Medicine, and other prestigious medical journals. Dr. Mastrianni is the recipient of many awards and honors. Recently, he was named the Helen M. McLoraine Neuroscience Investigator of the Brain Research Foundation and was appointed as an expert reviewer for the ECRI Institute of the U.S. Agency for Health Care Research and Quality. He has been reappointed to a neuroscience advisory committee of the U.S. Food and Drug Administrations (FDA). Also a dedicated educator, Dr. Mastrianni teaches and mentors students, residents, and doctoral and post-doctoral students.
One of Dr. Mastrianni's research projects, funded by a $1.5 million National Institutes of Health (NIH) grant, focuses on understanding animal and human prion diseases, which are progressive and infectious neurodegenerative disorders, such as mad cow disease and Creutzfeldt-Jakob disease. Prion diseases share many similarities with more common neurodegenerative conditions, such as Alzheimer's disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS). Therefore, Dr. Mastrianni’s studies aimed at understanding and correcting the underlying defect in prion diseases may likely help researchers to better understand these more common diseases, as well.
In another collaborative study, Dr. Mastrianni uses cognitive screening assessments combined with advanced brain imaging to predict whether individuals with mild memory problems will develop Alzheimer’s disease in the future.
An accomplished author, Dr. Mastrianni has published more than 40 scientific articles, as well as several book chapters and reviews. He is an invited contributor for Neurology, Journal Watch Neurology, Genetics in Medicine, Trends in Molecular Medicine, and other prestigious medical journals. Dr. Mastrianni is the recipient of many awards and honors. Recently, he was named the Helen M. McLoraine Neuroscience Investigator of the Brain Research Foundation and was appointed as an expert reviewer for the ECRI Institute of the U.S. Agency for Health Care Research and Quality. He has been reappointed to a neuroscience advisory committee of the U.S. Food and Drug Administrations (FDA). Also a dedicated educator, Dr. Mastrianni teaches and mentors students, residents, and doctoral and post-doctoral students.
Specialties
Areas of Expertise
UChicago Medicine Duchossois Center for Advanced Medicine - Hyde Park5758 S. Maryland Ave., Chicago IL 606371-888-824-0200
Board Certifications
- Neurology
Practicing Since
- 1989
Languages Spoken
- English
Medical Education
- McGill University
Residency
- Hospitals of the University of Pennsylvania
Fellowship
- University of California San Francisco Medical Center
Internship
- Hospitals of the University of Pennsylvania
Other Grad Education
- University of North Carolina,PhD
Memberships & Medical Societies
- American Academy of Neurology
- Society for Neuroscience
- American Association for the Advancement of Science
- New York Academy of Sciences
- World Federation of Neurology
- Sigma Xi
- American Neurological Association
News & Research
Insurance
- Aetna Better Health *see insurance page
- Aetna HMO (specialists only)
- Aetna Medicare Advantage HMO & PPO
- Aetna POS
- Aetna PPO
- BCBS Blue Precision HMO (specialists only)
- BCBS HMO (HMOI) (specialists only)
- BCBS Medicare Advantage HMO & PPO
- BCBS PPO
- Cigna HMO
- Cigna POS
- Cigna PPO
- CountyCare *see insurance page
- Humana Medicare Advantage Choice PPO
- Humana Medicare Advantage Gold Choice PFFS
- Humana Medicare Advantage Gold Plus HMO
- Medicare
- Multiplan PPO
- PHCS PPO
- United Choice Plus POS/PPO
- United Choice HMO (specialists only)
- United Options (PPO)
- United Select (HMO & EPO) (specialists only)
- United W500 Emergent Wrap
- University of Chicago Health Plan (UCHP)
Our list of accepted insurance providers is subject to change at any time. You should contact your insurance company to confirm UChicago Medicine participates in their network before scheduling your appointment. If your insurance company is not listed here, or if you have any other questions, please contact Managed.Care@uchospitals.edu.