UChicago Faculty Physician
James Mastrianni, MD, PhD
James Mastrianni, MD, PhD
UChicago Faculty Physician
Professor of Neurology
Professor of Neuroscience Institute
Co-Director, Center for Comprehensive Care and Research on Memory Disorders
Director, Memory Center
Specialties
- Neurology
Locations
- Chicago - Hyde Park
- Chicago - South Shore
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- About
- Specialties & Areas of Expertise
- Locations & Patient Information
- Education & Research
- Accepted Insurance
- External Professional Relationships
James Mastrianni, MD, PhD, is an expert in memory disorders and other neurodegenerative conditions. Working on a team of geriatricians, neurologists and neuropsychologists, Dr. Mastrianni provides diagnostic evaluation and long-term management of patients with Alzheimer's disease and related dementias. In a special clinic, he also evaluates patients referred to him with atypical dementias, which are unusual dementias for which a clear diagnosis cannot yet be determined. In addition to providing effective care for these patients, Dr. Mastrianni and his colleagues conduct clinical and basic science research to better understand and treat neurodegenerative diseases.
One of Dr. Mastrianni's research projects, funded by a $1.5 million National Institutes of Health (NIH) grant, focuses on understanding animal and human prion diseases, which are progressive and infectious neurodegenerative disorders, such as mad cow disease and Creutzfeldt-Jakob disease. Prion diseases share many similarities with more common neurodegenerative conditions, such as Alzheimer's disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS). Therefore, Dr. Mastrianni’s studies aimed at understanding and correcting the underlying defect in prion diseases may likely help researchers to better understand these more common diseases, as well.
In another collaborative study, Dr. Mastrianni uses cognitive screening assessments combined with advanced brain imaging to predict whether individuals with mild memory problems will develop Alzheimer’s disease in the future.
An accomplished author, Dr. Mastrianni has published more than 40 scientific articles, as well as several book chapters and reviews. He is an invited contributor for Neurology, Journal Watch Neurology, Genetics in Medicine, Trends in Molecular Medicine, and other prestigious medical journals. Dr. Mastrianni is the recipient of many awards and honors. Recently, he was named the Helen M. McLoraine Neuroscience Investigator of the Brain Research Foundation and was appointed as an expert reviewer for the ECRI Institute of the U.S. Agency for Health Care Research and Quality. He has been reappointed to a neuroscience advisory committee of the U.S. Food and Drug Administrations (FDA). Also a dedicated educator, Dr. Mastrianni teaches and mentors students, residents, and doctoral and post-doctoral students.
One of Dr. Mastrianni's research projects, funded by a $1.5 million National Institutes of Health (NIH) grant, focuses on understanding animal and human prion diseases, which are progressive and infectious neurodegenerative disorders, such as mad cow disease and Creutzfeldt-Jakob disease. Prion diseases share many similarities with more common neurodegenerative conditions, such as Alzheimer's disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS). Therefore, Dr. Mastrianni’s studies aimed at understanding and correcting the underlying defect in prion diseases may likely help researchers to better understand these more common diseases, as well.
In another collaborative study, Dr. Mastrianni uses cognitive screening assessments combined with advanced brain imaging to predict whether individuals with mild memory problems will develop Alzheimer’s disease in the future.
An accomplished author, Dr. Mastrianni has published more than 40 scientific articles, as well as several book chapters and reviews. He is an invited contributor for Neurology, Journal Watch Neurology, Genetics in Medicine, Trends in Molecular Medicine, and other prestigious medical journals. Dr. Mastrianni is the recipient of many awards and honors. Recently, he was named the Helen M. McLoraine Neuroscience Investigator of the Brain Research Foundation and was appointed as an expert reviewer for the ECRI Institute of the U.S. Agency for Health Care Research and Quality. He has been reappointed to a neuroscience advisory committee of the U.S. Food and Drug Administrations (FDA). Also a dedicated educator, Dr. Mastrianni teaches and mentors students, residents, and doctoral and post-doctoral students.
Specialties
Areas of Expertise
UChicago Medicine Duchossois Center for Advanced Medicine - Hyde Park5758 S. Maryland Ave., Chicago IL 606371-888-824-0200
Board Certifications
- Neurology
Practicing Since
- 1989
Languages Spoken
- English
Medical Education
- McGill University
Internship
- Hospitals of the University of Pennsylvania
Residency
- Hospitals of the University of Pennsylvania
Fellowship
- University of California San Francisco Medical Center
Other Grad Education
- University of North Carolina,PhD
Memberships & Medical Societies
- American Academy of Neurology
- American Association for the Advancement of Science
- American Neurological Association
- New York Academy of Sciences
- Sigma Xi
- Society for Neuroscience
- World Federation of Neurology
News & Research
Insurance
- Aetna Better Health *see insurance page
- Aetna HMO (specialists only)
- Aetna Medicare Advantage HMO & PPO
- Aetna POS
- Aetna PPO
- BCBS Blue Precision HMO (specialists only)
- BCBS HMO (HMOI) (specialists only)
- BCBS Medicare Advantage HMO & PPO
- BCBS PPO
- Cigna HMO
- Cigna POS
- Cigna PPO
- CountyCare *see insurance page
- Humana Medicare Advantage Choice PPO
- Humana Medicare Advantage Gold Choice PFFS
- Humana Medicare Advantage Gold Plus HMO
- Medicare
- Multiplan PPO
- PHCS PPO
- United Choice Plus POS/PPO
- United Choice HMO (specialists only)
- United Options (PPO)
- United Select (HMO & EPO) (specialists only)
- United W500 Emergent Wrap
- University of Chicago Health Plan (UCHP)
Our list of accepted insurance providers is subject to change at any time. You should contact your insurance company to confirm UChicago Medicine participates in their network before scheduling your appointment. If you have questions regarding your insurance benefits at UChicago Medicine, please contact our financial counseling team at OPSFinancialCounseling@uchospitals.edu.
UChicago Medicine is committed to fostering a corporate culture of ethical behavior and integrity in all matters related to compliance with the laws and regulations that govern the delivery of healthcare. This aspiration is central to supporting patient care, research, and teaching at UChicago Medicine.
Some of our physicians and health professionals collaborate with external pharmaceutical, medical device, or other medical related entities to develop new treatments and products to improve clinical outcomes for patients. In some instances, the physician has ownership interests in the external entity and/or is compensated for advising or speaking about the entity’s products or treatments. These payments may include compensation for consulting and speaking engagements, equity, and/or royalties for products invented by our physicians. To assure objectivity and integrity in patient care, UChicago Medicine requires all physicians and health professionals to report their relationships and financial interests with external entities on an annual basis. This information is used to review relationships and transactions that might give rise to potential financial conflicts of interest, and when considered to be significant a management plan to mitigate any biases is created.
If you are a patient at UChicago Medicine and would like more information about your physician’s external relationships, please talk with your physician. You may also visit the Centers for Medicare & Medicaid Services (CMS) Open Payments website at https://openpaymentsdata.cms.gov/ . CMS Open Payments is a national disclosure program that promotes a more transparent and accountable health care system. It houses a publicly accessible database of payments that reporting entities, including drug and medical device companies, make to covered recipients like physicians and hospitals.
Information in the CMS Open Payments database could potentially contain inaccurately reported and out of date payment information. All information is open to personal interpretation, if there are questions about the data, patients and their advocates should speak directly to their health care provider for a better understanding.
Some of our physicians and health professionals collaborate with external pharmaceutical, medical device, or other medical related entities to develop new treatments and products to improve clinical outcomes for patients. In some instances, the physician has ownership interests in the external entity and/or is compensated for advising or speaking about the entity’s products or treatments. These payments may include compensation for consulting and speaking engagements, equity, and/or royalties for products invented by our physicians. To assure objectivity and integrity in patient care, UChicago Medicine requires all physicians and health professionals to report their relationships and financial interests with external entities on an annual basis. This information is used to review relationships and transactions that might give rise to potential financial conflicts of interest, and when considered to be significant a management plan to mitigate any biases is created.
If you are a patient at UChicago Medicine and would like more information about your physician’s external relationships, please talk with your physician. You may also visit the Centers for Medicare & Medicaid Services (CMS) Open Payments website at https://openpaymentsdata.cms.gov/ . CMS Open Payments is a national disclosure program that promotes a more transparent and accountable health care system. It houses a publicly accessible database of payments that reporting entities, including drug and medical device companies, make to covered recipients like physicians and hospitals.
Information in the CMS Open Payments database could potentially contain inaccurately reported and out of date payment information. All information is open to personal interpretation, if there are questions about the data, patients and their advocates should speak directly to their health care provider for a better understanding.