Mark J. Ratain, MD

Hematology and Oncology (Cancer) | More

Leon O. Jacobson Professor of Medicine Director, Center for Personalized Therapeutics
Associate Director, Clinical Sciences for Comprehensive Cancer Center
Chief, Hospital Pharmacology

A clinically integrated network of physicians and providers employed by UChicago Medicine who offer care in inpatient, community, ambulatory, acute care or extended care settings.


Mark J. Ratain, MD, is an expert in the use of investigational agents to treat advanced solid tumors in addition to his specialty in the clinical pharmacology of marketed drugs. Dr. Ratain has an interest in the clinical development of new oncology drugs, and more recently, his research focused on the use of pharmacogenomics to guide personalized prescribing and interventional pharmacoeconomics. Through this research, he is aiming to decrease prescribing costs through the use of lower dosages, less frequent dosing, shorter duration of treatment, and/or therapeutic substitution.

Dr. Ratain is an international leader in phase I clinical trials, pharmacogenetics and clinical trial methodology, and he created the new discipline of interventional pharmacoeconomics. His work can be found in more than 500 published articles and book chapters.

He has also received several awards/recognitions for his dedication to improving medicine. In 2015, Dr. Ratain received the Award in Excellence in Clinical Pharmacology from the Pharmaceutical Research and Manufacturers of America Foundation. In 2016 he was the nominee (Scientific Advances), from the Giants of Cancer, OncLive and in 2019 Dr. Ratain presented the Gruber Lectureship at Thomas Jefferson University.

Areas of Expertise

  • Solid Tumors

Medical Education

  • Yale University School of Medicine


  • Johns Hopkins Medicine


  • Johns Hopkins Medicine


  • University of Chicago Medicine

Memberships & Medical Societies

  • American Association for Cancer Research
  • Central Society for Clinical and Translational Research
  • Association of American Physicians
  • American Society of Hematology
  • American Society of Clinical Oncology
  • American Society for Clinical Pharmacology and Therapeutics
  • American Federation for Clinical Research
  • American College of Physicians
  • American Association for the Advancement of Science
  • European Society for Medical Oncology
  • Aetna POS
  • Aetna HMO
  • Aetna PPO
  • BCBS Blue Precision HMO
  • Cigna HMO
  • Cigna POS
  • Cigna PPO
  • CountyCare
  • Coventry Health Plan PPO
  • Great West PPO
  • Illinicare*
  • Medicare
  • Multiplan PPO
  • United Choice / Choice Plus
  • United Options (PPO)
  • United Select (HMO & EPO)
  • United W500 Emergent Wrap
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At a Glance

Practicing Since1986

Board Certifications

  • Internal Medicine
  • Medical Oncology
  • Hematology
  • Clinical Pharmacology

Languages Spoken

  • English