Mark J. Ratain, MD

UChicago Faculty Physicians

Mark J. Ratain, MD

Leon O. Jacobson Professor of Medicine Director, Center for Personalized Therapeutics
Chief, Hospital Pharmacology

Mark J. Ratain, MD, is an expert in the use of investigational agents to treat advanced solid tumors in addition to his specialty in the clinical pharmacology of marketed drugs. Dr. Ratain has an interest in the clinical development of new oncology drugs, and more recently, his research focused on the use of pharmacogenomics to guide personalized prescribing and interventional pharmacoeconomics. Through this research, he is aiming to decrease prescribing costs through the use of lower dosages, less frequent dosing, shorter duration of treatment, and/or therapeutic substitution.

Dr. Ratain is an international leader in phase I clinical trials, pharmacogenetics and clinical trial methodology, and he created the new discipline of interventional pharmacoeconomics. His work can be found in more than 500 published articles and book chapters.

He has also received several awards/recognitions for his dedication to improving medicine. In 2015, Dr. Ratain received the Award in Excellence in Clinical Pharmacology from the Pharmaceutical Research and Manufacturers of America Foundation. In 2016 he was the nominee (Scientific Advances), from the Giants of Cancer, OncLive and in 2019 Dr. Ratain presented the Gruber Lectureship at Thomas Jefferson University.

Areas of Expertise

  • Solid Tumors

Board Certifications

  • Internal Medicine
  • Hematology
  • Medical Oncology

Memberships & Medical Societies

  • American College of Physicians
  • American Association for Cancer Research
  • Central Society for Clinical and Translational Research
  • American Association for the Advancement of Science
  • American Society of Hematology
  • Association of American Physicians
  • European Society for Medical Oncology
  • American Federation for Clinical Research
  • American Society for Clinical Pharmacology and Therapeutics
  • American Society of Clinical Oncology

Practicing Since

  • 1986

Languages Spoken

  • English

Medical Education

  • Yale University


  • The Johns Hopkins Hospital


  • Johns Hopkins Hospital


  • University of Chicago Medicine

News & Research

View Published Papers
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  • Aetna PPO
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  • Cigna POS
  • Cigna PPO
  • CountyCare *see insurance page
  • Aetna Better Health *see insurance page
  • Medicare
  • Multiplan PPO
  • United Choice Plus POS/PPO
  • United Options (PPO)
  • United Select (HMO & EPO) (specialists only)
  • United W500 Emergent Wrap
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  • BCBS Medicare Advantage HMO & PPO
  • Humana Medicare Advantage Choice PPO
  • Humana Medicare Advantage Gold Choice PFFS
  • Humana Medicare Advantage Gold Plus HMO
  • United Choice HMO (specialists only)
  • University of Chicago Health Plan (UCHP)

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