Prostate cancer is one of the most common and deadly cancers for American men. To better assist men at risk for the disease, we created the University of Chicago Medicine High-Risk and Advanced Prostate Cancer Clinic. The program provides a comprehensive genetic evaluation and multifaceted screening plan for men with an increased prostate cancer risk. If you’ve been recently diagnosed with aggressive forms of prostate cancer, our team also offers novel treatment strategies as well as access to leading-edge clinical trials.

Why Choose Us?

Our team works with men who’ve been diagnosed with aggressive prostate cancer as well as those who have an elevated risk for developing prostate cancer in the future. 

Prostate cancer risk factors:

  • A family history of prostate cancer (including your brothers, father, grandfathers or uncles) 
  • Multiple family members who’ve had prostate cancer 
  • A single family member who's had high-grade, advanced or metastatic prostate cancer
  • African ancestry
  • Ashkenazi Jewish ancestry
  • You or certain family members have certain genetic risk factors (e.g. BRCA1, BRCA2, ATM, CHEK2)
  • A family history of breast, ovarian or pancreatic cancer.

Indications of aggressive or high-risk prostate cancer:

  • Metastases (cancer in more than one location) at your initial diagnosis
  • A PSA (prostate-specific antigen) score that’s greater than 20 ng/ml 
  • A Gleason score that’s greater than or equal to 8 and a Gleason grade group that’s greater than or equal to 4 
  • High volume of Gleason 7 and a Gleason grade group that’s greater than or equal to 3
  • Evidence that your prostate cancer is extending outside the prostate capsule into the seminal vesicles or pelvic lymph nodes

Clinical Trials

UChicago Medicine is a major center for conducting prostate cancer research through the National Cancer Institute and private sponsors. Additionally, UChicago Medicine sponsors many clinical trials that are designed by our own prostate cancer experts. 

These clinical trials are testing novel surgical, radiation and medical treatments to fight prostate cancer and improve patients’ quality of life. Men who participate in prostate cancer research studies have a chance to benefit from treatments that have shown promise in previous research but are not yet widely available to the public. 

If you’ve already been diagnosed with prostate cancer, you may be eligible to participate in a clinical trial to test new treatment strategies

Team-Based Care

Our clinic includes a multidisciplinary team of specialists who provide high-quality screening and treatment strategies for men with prostate cancer, including:

  • Access to novel blood, urine and tissue-based biomarkers
  • Advanced, high-quality multiparametric 3T MRI imaging
  • Access to the latest clinical trials to improve cure rates for men with high-risk prostate cancer.

Our expert team includes urologists, geneticists, medical oncologists, radiation oncologists, radiologists, pathologists, care navigators and research scientists who work together to provide the most advanced clinical care for men with prostate cancer.

Beyond our treatment strategies, we’re also committed to conducting comprehensive patient profiling and biobanking to advance scientific knowledge and ultimately improve prostate cancer treatment for men everywhere.

High Risk & Advanced Prostate Cancer Clinic Physician Team