Mark A. Applebaum, MD

Pediatric Hematology & Oncology (Pediatric Cancer) | More

Assistant Professor of Pediatrics

UChicago Faculty Physicians hold faculty positions with the University of Chicago and provide care for patients on the academic health system’s main campus in Hyde Park and in care centers throughout the Chicago region.

Mark Applebaum, MD, is an expert in pediatric cancers and blood diseases. He has a special interest in the treatment of neuroblastoma, sarcomas and solid tumors.

Dr. Applebaum is actively researching several aspects of neuroblastoma and pediatric solid tumors. His research harnesses the power of large genomic data sets in pediatric oncology to develop new "cancer-specific" targeted strategies that will ultimately improve outcomes while minimizing risk.

Dr. Applebaum also focuses his research on how the low-oxygen environment of tumors makes cancer cells more resistant to standard therapies. Identifying the genes and cellular pathways responsible for making cancer more aggressive in these conditions may ultimately open new avenues for novel therapeutic options.

Dr. Applebaum's research is supported in part by the University of Chicago Cancer Research Foundation Auxiliary Board. Additionally, he is the recipient of numerous awards, including the Brigid Leventhal Merit Award from the Conquer Cancer Foundation, the Bear Necessities Foundation Young Investigator Award, and the AACR-Aflac Inc. Scholar-in-Training award.

Medical Education

  • Northwestern University Feinberg School of Medicine


  • University of California San Francisco Health


  • University of California San Francisco Health


  • University of Chicago Medicine

Memberships & Medical Societies

  • American Society of Clinical Oncology
  • American Association for Cancer Research
  • American Society of Pediatric Hematology/Oncology
  • American Society for Clinical Pharmacology and Therapeutics
  • Aetna HMO (specialists only)
  • Aetna POS
  • Aetna PPO
  • BCBS Blue Precision HMO (specialists only)
  • BCBS HMO (HMOI) (specialists only)
  • Cigna HMO
  • Cigna POS
  • Cigna PPO
  • CountyCare *see insurance page
  • Aetna Better Health *see insurance page
  • Medicare
  • Multiplan PPO
  • United Choice Plus POS/PPO
  • United Options (PPO)
  • United Select (HMO & EPO) (specialists only)
  • United W500 Emergent Wrap
  • Aetna Medicare Advantage HMO & PPO
  • BCBS Medicare Advantage HMO & PPO
  • Humana Medicare Advantage Choice PPO
  • Humana Medicare Advantage Gold Choice PFFS
  • Humana Medicare Advantage Gold Plus HMO
  • United Choice HMO (specialists only)
  • University of Chicago Health Plan (UCHP)
To Request an Appointment

Comer Children's Hospital - Hyde Park

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At a Glance

Practicing Since2011

Board Certifications

  • Pediatrics

Languages Spoken

  • English