At the Forefront - UChicago Medicine

IgG4-Related Disease (IgG4-RD)

UChicago Medicine IgG4-Related Disease Clinical Consortium (IGGCC)

UChicago Medicine is proud to offer the Midwest’s only dedicated clinical consortium for IgG4-Related Disease (IgG4-RD), a rare but serious inflammatory condition that can affect nearly every organ system in the body. IgG4-RD is characterized by immune system activation, organ inflammation and tissue fibrosis, which can lead to progressive and irreversible organ damage if left untreated.

Our multidisciplinary consortium brings together experts from rheumatology, gastroenterology, nephrology, pathology, radiology, and other specialties to provide comprehensive, coordinated care. We specialize in accurate diagnosis through detailed evaluation of symptoms, imaging, blood tests, biopsies and treatment response, ensuring patients receive timely and precise diagnoses.

Treatment plans are individualized and may include steroid therapy as a first-line approach, with access to emerging therapies and clinical research aimed at improving long-term outcomes and preventing disease relapse.

Patients can access expert care at multiple convenient locations across the Chicago area, including:

  • Hinsdale
  • Hyde Park
  • River East
  • Crown Point
  • Orland Park

UChicago Medicine’s IgG4-RD Clinical Consortium is committed to advancing understanding and treatment of this complex disease while providing patients with the highest level of expert care close to home.

For more information or to refer a patient, call 773-702-6140.

Our Physicians

Bradford Chong, MDBradford Chong, MD

Gastroenterology

Michael Macklin, MDMichael Macklin, MD

Rheumatology

Pankti Reid, MD, MPHPankti Reid, MD, MPH

Rheumatology

John Hart, MDJohn Hart, MD

Pathology

Namrata Setia, MDNamrata Setia, MD

Pathology

Lindsay Alpert, MDLindsay Alpert, MD

Pathology

Understanding IgG4-Related Disease (IgG4-RD)

IgG4-related disease (IgG4-RD) is a rare but serious inflammatory condition that can affect nearly every organ system in the body, including the pancreas, bile ducts, lungs, kidneys, and multiple glands. It can be challenging to diagnose and, if left untreated, can result in progressive and irreversible organ damage. There is also a major need to identify new treatments that can effectively treat this condition.

Currently there are few centers of expertise in IgG4-RD in the country. University of Chicago is at the forefront of medicine as the sole clinical consortium for IgG4-RD in the Midwest. Our clinical consortium comprises experts from multiple specialties who are committed to providing accurate diagnoses, developing comprehensive treatment plans, and streamlining patients’ medical care for this disease.

The information below will give you answers to frequently asked questions about IgG4-RD and connect you with members of the UChicago IgG4-RD Clinical Consortium (IGGCC).

Our Locations

Request an Appointment

We are currently experiencing a high volume of inquiries, leading to delayed response times. For faster assistance, please call 1-888-824-0200 to schedule your appointment.

If you have symptoms of an urgent nature, please call your doctor or go to the emergency room immediately.

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By submitting this form you acknowledge the risk of sending this information by email and agree not to hold the University of Chicago or University of Chicago Medical Center liable for any damages you may incur as a result of the transfer or use of this information. The use or transmittal of this form does not create a physician-contact relationship. More information regarding the confidentiality of this request can be found in our Privacy Policy.