Harnessing the Immune System to Fight Cancer
Your immune system protects you from infection, illness and substances that can harm your body. Immunotherapy refers to a medical treatment that turns the power of the immune system against disease. Cancer immunotherapy acts on the cells of the immune system to seek out, recognize and attack cancer.
Types of Cancer Immunotherapy
Several types of immunotherapy are approved for use to treat cancer or are being studied through clinical trials. The different kinds of immunotherapies work in different ways to treat cancer. Some boost the immune system to work against cancer, while others train the immune system to seek out and attack cancer cells.
- CAR T-cell therapy involves the removal of T cells from a patient’s blood. These disease-fighting cells are then supercharged to recognize and destroy cancer cells. The University of Chicago Medicine was the first medical center in Illinois certified to offer CAR T-cell therapy.
- Immune checkpoint inhibitors are drugs that block the proteins that cancer cells use to disarm an immune response, allowing T cells to attack and destroy tumor cells.
- Monoclonal antibodies are man-made versions of immune system proteins, designed to attack a specific part of a cancer cell.
- Cytokines are proteins made by your body’s cells that play a role in the body’s immune response to illness, including cancer. Interferon and interleukins are cytokines used to fight cancer.
- Cancer vaccines involve substances put in the body to activate an immune response that helps prevent or treat cancer.
UChicago Medicine physicians lead immunotherapy clinical trials for the following types of cancer:
- Leukemia (acute lymphoblastic leukemia)
- Multiple Myeloma
- Head and neck
- Lung (non-small)
- Solid tumors
CAR T-Cell Therapy
CAR T-cell therapy supercharges a patient's white blood cells to seek out and destroy cancer cells. Research at UChicago Medicine played a key role in the development of this exciting new immunotherapy.View videos and learn more