UChicago Medicine Comprehensive Cancer Center

The Comprehensive Cancer Center Protocol Review and Monitoring System (PRMS), an NCI-mandated activity, reviews the scientific merit, priority, and progress of all cancer clinical trials conducted at the University of Chicago, regardless of sponsorship, department, or type.

The Comprehensive Cancer Center PRMS comprises two committees:

  • The Clinical Trials Review Committee (CTRC), which conducts the initial protocol review
  • The Scientific and Accrual Monitoring (SAM) Committee, which is responsible for annual reviews to evaluate scientific progress and study accrual

Both are under the overall management of the Comprehensive Cancer Center Associate Director for Clinical Sciences and the Clinical Research Advisory Committee (CRAC). For cancer-related trials, institutional review board (IRB) approval is not granted until the protocol has received CTRC approval. In addition, the PRMS has the authority to close trials that do not demonstrate adequate scientific progress based on poor accrual or other factors.

Clinical Trials Review Committee

  • Chair: Hedy Kindler, MD
  • Vice Chair: Russell Szmulewitz, MD

The committee meets monthly (meeting and submission dates, and information about accessing forms can be obtained from the PRMS Manager, Amber Burnett — 5-0352, aburnett@medicine.bsd.uchicago.edu)

Scientific and Accrual Monitoring (SAM) Committee

Chair: Lucy Godley, MD, PhD

Vice Chair: Steven Chmura, MD, PhD

The committee meets monthly and studies are reviewed every 6-12 months for as long as they are actively enrolling new participants.