Understanding risks for childhood cancer survivors

clinician listening to girl

Survivors of childhood cancer have every reason to celebrate after experiencing harrowing diagnoses and difficult treatments during their most formative years.

But research shows that even if they are cured, survivors aren’t out of the woods: Chemotherapy and radiation treatments can leave survivors at risk for a host of later-in-life complications, including cardiac disease and secondary cancers.

Female childhood cancer survivors — even if they did not receive radiation treatments to their chest — are six times more likely than the general population to be diagnosed with breast cancer. For those who did receive chest radiation, that chance increases exponentially and is on par with those who have the BRCA1 or BRCA2 mutations.

Tara Henderson, MD, MPH, a hematologist/oncologist at the University of Chicago Medicine Comer Children’s Hospital and director of the Childhood Cancer Survivors Center, has spent her career studying outcomes and potential interventions for this group. Recently, she and her collaborators set out to discover whether survivors diagnosed with breast cancer had the same mortality rate as breast cancer patients who had previously been cancer-free.

We want survivors to stay engaged throughout their lifetimes, to know that once they are cured, they still need to know their risks.

They studied the cases of 274 female cancer survivors who had been diagnosed with cancer between 1970 and 1986 (before they were 21) and were subsequently diagnosed with breast cancer as adults. They then compared their cases to a group of more than 1,000 breast cancer patients who hadn’t been diagnosed with cancer previously.

They found that childhood cancer survivors had only a slightly higher chance of dying from breast cancer compared to the control group. While that was good news, there was a catch. The study showed that childhood cancer survivors were five times more likely to die as a result of other diseases, including secondary cancers and heart and lung diseases. The results were published in the Journal of Clinical Oncology.

“We know that for children who receive cancer treatments, any developing organ can be impacted by chemotherapy and radiation,” Henderson said. “That puts them at risk for developing heart failure and lung disease, along with secondary cancers, and this study really showed how pervasive those problems are.”

Studies like this show the need to provide specialized care to this group as they age, Henderson says. She and her collaborators are developing a breast cancer risk prediction model for survivors, and she continues to expand services through the University of Chicago Medicine Childhood, Adolescent and Young Adult Cancer Survivor Center, which she directs.

Henderson sees survivors of both childhood and young adult cancers and provides them with ongoing surveillance and interventions to ensure any new problems are caught early. That includes having open communication with cancer survivors’ primary care doctors, who are often unaware of the ongoing risks in this population.

The ultimate goal is to minimize the health effects and identify diseases like breast cancer early. Since outcomes in this population are similar to breast cancer outcomes in the general population, diagnosing breast cancer when it is stage 1 often leads to a 90 percent cure rate.

“We want survivors to stay engaged throughout their lifetimes, to know that once they are cured, they still need to know their risks,” Henderson said. “That doesn’t necessarily mean they will have issues, but we want them to be empowered with information. We don’t want them to get lost in follow-up.”

Additional authors on the study include Chaya S. Moskowitz, Joanne F. Chou, and Danielle Novetsky Friedman from Memorial Sloan Kettering Cancer Center; Joseph P. Neglia and Lucie M. Turcotte from the University of Minnesota; Ann H. Partridge and Lisa R. Diller from Dana-Farber Cancer Institute; Rebecca M. Howell from MD Anderson Cancer Center; Dana Barnea from Tel Aviv Sourasky Medical Center, Israel; Lindsay M. Morton from the National Cancer Institute; Michael A. Arnold from Nationwide Children’s Hospital; Wendy M. Leisenring from Fred Hutchinson Cancer Research Center; Gregory T. Armstrong and Leslie L. Robison from St Jude Children’s Research Hospital; and Kevin C. Oeffinger from Duke University.

Citation: "Mortality After Breast Cancer Among Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study," Journal of Clinical Oncology, July 1, 2019. DOI: 10.1200/JCO.18.02219.

Pediatric oncologist Tara Henderson, MD

Tara Henderson, MD, MPH

Tara Henderson is an expert in the diagnosis and treatment of pediatric cancers. She serves as director of the UChicago Medicine Childhood Cancer Survivors Center, a program aimed at the prevention and treatment of long-term issues associated with cancer therapy.

View Dr. Henderson's physician profile