Kovler Diabetes Center Research Studies

Expanding knowledge, advancing understanding and applying scientific discoveries to enhance the health and lives of patients with diabetes is a hallmark of the Kovler Diabetes Center.

Building on a long history of seminal diabetes-related research at the University of Chicago, our affiliated principal investigators today work in a number of disciplines with implications for diabetes.

Researchers at Kovler and the University of Chicago enjoy the collaborative opportunities available across campus and beyond including our onsite Diabetes Research and Training Center, and with individual labs within the Section of Endocrinology, Diabetes & Metabolism. Basic scientists and clinical researchers as well as those looking for unique postdoctoral training will find unparalleled opportunities to pursue research at Kovler and the University of Chicago.

For more information on screening for type 1 diabetes or if you are interested in new onset type 1 diabetes trials, please contact kovlerstudies@uchicago.edu.

Clinical Research Opportunities

EquiT1D: Using Technology to Address Disparities and Promote Healthcare Equity in Type 1 Diabetes

This study, Using Technology to Address Disparities and Promote Healthcare Equity in Type 1 Diabetes or EquiT1D, aims to address disparities in type 1 diabetes by helping adult patients with type 1 diabetes who have been hospitalized with diabetic ketoacidosis more than once in the last five years obtain continuous glucose monitors (CGMs). A patient navigator will then help the patient learn to use their CGM and contact them to follow up throughout the course of the study.

The EquiT1D research team led by Celeste Thomas, MD, MS, will evaluate this intervention’s impact on participants’ diabetes measurements and self-management practices. Its finding could create a new standard of care for diabetes management. Contact Elizabeth Murphy, MS, RDN, LDN for more information.

MAP-T1D: Using MRI Technology to Investigate Changes in the Pancreas

The Multicenter Assessment of the Pancreas in Type 1 Diabetes (MAP-T1D) is an international team of researchers that focus on using magnetic resonance imaging (MRI) to investigate changes in pancreas volume and microarchitecture in individuals with diabetes. Center Director Louis Philipson, MD, PhD, and Siri Atma Greeley, MD, PhD, are the principal investigators at UChicago Medicine for the MAP-T1D project.

Contact Demetra Braun at Demetra.Braun@bsd.uchicago.edu or visit https://www.map-t1d.com/ for more information.

ONWARDS 11

Rare and Atypical Diabetes Network (RADIANT)

The Rare and Atypical Diabetes Network (RADIANT) trial, for which Center Director Louis Philipson, MD, PhD, and Siri Atma Greeley, MD, PhD, are the principal investigators, is discovering and defining rare and atypical forms of diabetes, a signature project of the Kovler Diabetes Center.

RADIANT is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). RADIANT is a network of universities, hospitals and clinics across the United States dedicated to better understanding atypical diabetes. Our team of academic institutions and scientists collaborate with physicians and healthcare groups to identify people with atypical diabetes and learn more about their health.

Contact Ava Jerred, at ava.jerred@bsd.uchicago.edu or visit https://www.atypicaldiabetesnetwork.org/ for more information.

TArgeting Type 1 Diabetes Using POLyamines (TADPOL)

UChicago Medicine is participating in a phase 2 clinical trial, sponsored by Indiana University. This study will assess the effectiveness, safety, and tolerability of Difluoromethylornithine (DFMO) to preserve insulin production in people living with type 1 diabetes.

For more information about the study and to learn if you may be eligible, please contact Cathleen Mulcahy at 773-702-9968 or visit https://clinicaltrials.gov/study/NCT05594563.

Vertex: Islet Infusion for Type 1 Diabetes

UChicago Medicine is participating in a new clinical research study of an investigational infusion of islets in individuals who have been diagnosed with type 1 diabetes with low blood sugar and impaired hypoglycemic awareness. In this study, islets manufactured from stem cells are infused into the liver with a goal of providing replacement cells producing insulin for cells that have been lost.

Contact: Lindsay Basto, RN MSN for more information.

Diabetes Care at UChicago Medicine

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