Michael Spiotto, MD, PhD

Radiation Oncology | More

Associate Professor of Radiation and Cellular Oncology

A clinically integrated network of physicians and providers employed by UChicago Medicine who offer care in inpatient, community, ambulatory, acute care or extended care settings.


Michael Spiotto, MD, PhD, specializes in treating patients with head and neck cancer. Whenever possible, he uses image-guided radiation therapy to target a tumor more precisely while reducing damage to surrounding tissue.

Dr. Spiotto currently serves as the primary investigator on a study examining the role of non-genotoxic inhibitors (agents that slow chemical reactions without damaging genetic tissue) in the spread of head and neck cancers caused by human papillomavirus (HPV). By studying the origin of HPV-induced cancers and understanding how they metastasize, he hopes to develop new treatment protocols and prevent relapse.

An accomplished author, Dr. Spiotto's work has been published in scientific journals such as the Proceedings of the National Academy of Sciences, Immunity, Nature Medicine and Cancer Research. In addition, he has been a the recipient of several notable awards, including: the American Board of Radiology Holman Pathway, given to a trainee with exceptional clinical and research abilities; the University of Chicago's Leon O. Jacobson Basic Science Prize; and the John Van Prohaska Award for outstanding potential in teaching, research and clinical medicine.


Areas of Expertise

Medical Education

  • University of Chicago Pritzker School of Medicine


  • Memorial Sloan Kettering Cancer Center


  • Stanford Health Care

Other Grad Education

  • PhD, University of Chicago

Memberships & Medical Societies

  • Radiological Society of North America
  • American Society for Radiation Oncology
  • Association of Residents in Radiation Oncology
  • Aetna POS
  • Aetna HMO
  • Aetna PPO
  • BCBS Blue Precision HMO
  • Cigna HMO
  • Cigna POS
  • Cigna PPO
  • CountyCare
  • Coventry Health Plan PPO
  • Great West PPO
  • Illinicare*
  • Medicare
  • Multiplan PPO
  • United Choice / Choice Plus
  • United Options (PPO)
  • United Select (HMO & EPO)
  • United W500 Emergent Wrap
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At a Glance

Practicing Since2010

Languages Spoken

  • English