John Blair, MD

UChicago Faculty Physicians

John Blair, MD

Associate Professor of Medicine

[MUSIC PLAYING] I'm John Blair. I'm an interventional cardiologist, which means that I place stents, valves, and do other procedures on the heart. So the reason I wanted to become a physician was because it's a great intersection of being able to interact in very critical portions of people's lives and be a part of their lives and helping them while at the same time using science and cutting-edge technology to use those tools to help them.

My main clinical interests are helping people with various forms of congestive heart failure and looking for creative and innovative ways of helping those patients, either with medications, and, because I'm an interventional cardiologist, also to find solutions and procedures that may help with their symptoms and overall lifespan.

My philosophy of care is very patient-centered and trying to assess the patient's overall needs and prioritize their needs and, over time, work with them. It's not just a one-visit thing. I'm their physician, their cardiologist, but also can take care of some other things that come up during the whole relationship and over the whole course of their lives and their care.

There's a lot of rewarding aspects. Just being able to take care of patients and take part in patient's care is very rewarding. And to be able to teach that to medical students, residents, and fellows is also very rewarding. But I think just having that trust and that relationship with the patient to build on that and to help get them toward wellness.


John Blair, MD, FACC, is a cardiologist who specializes in the care of complex coronary artery disease, mitral and aortic valve disease and congestive heart failure. Dr. Blair performs a wide range of procedures for the diagnosis and treatment of cardiovascular disease, including radial artery catheterization, balloon angioplasty, coronary stent placement, rotational orbital and excimer laser atherectomy, intravascular ultrasound and optical coherence tomography imaging and treatment of chronic total occlusions (CTOs).

He utilizes his experience in echocardiography and interventional cardiology in performing transcatheter mitral valve repair (MitraClip) procedures. As a member of the Heart and Vascular Center’s valve team, he is integral to the evaluation and treatment of aortic and mitral stenosis, utilizing techniques such as transcatheter aortic valve replacement (TAVR) and percutaneous balloon aortic and mitral valvuloplasty.

Dr. Blair is one of few cardiologists who perform coronary physiology studies, which aid in diagnosing coronary microvascular dysfunction in a range of challenging clinical scenarios. His research interests focus on coronary microvascular dysfunction in patients with various cardiovascular conditions, including heart failure with preserved ejection fraction (HFpEF).

Prior to joining the University of Chicago Medicine, Dr. Blair was a Major in the United States Air Force Medical Corps, where he served as staff cardiologist at the San Antonio Military Medical Center and Wilford Hall Medical Center in San Antonio, Texas.

Areas of Expertise

Board Certifications

  • Interventional Cardiology
  • Cardiovascular Disease

Memberships & Medical Societies

  • American College of Cardiology

Practicing Since

  • 2003

Languages Spoken

  • English

Medical Education

  • University of Chicago Pritzker School of Medicine


  • University of Chicago Medicine


  • University of Chicago Medicine


  • Northwestern Medicine

News & Research

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At The Forefront Live: Chest Pain Experts Answer Common Questions

Chest pain is a key symptom of coronary heart disease, the most common type of heart disease that kills 370,000 annually. Interventional cardiologists Sandeep Nathan, MD, and John Blair, MD, discuss chest pain's causes and treatments.

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