Gender
All
Age Group
16 Years to 80 Years
Accepting Healthy Volunteers
No
Inclusion Criteria:
- Confirmed diagnosis of UC
- Moderately to severely active UC assessed by mMS
- Bodyweight >= 40 kilogram (kg)
- Demonstrated inadequate response, loss of response and/or intolerance to at least
one protocol-specified conventional or advanced UC therapy
- Males and females of childbearing potential must meet protocol criteria for
contraception requirements
Exclusion Criteria:
- Currently known complications of UC (e.g. fulminant colitis, toxic megacolon)
- Current diagnosis of Crohn's disease (CD) or indeterminate colitis, microscopic
colitis, ischemic colitis, infectious colitis, radiation colitis
- Presence of an ostomy or ileoanal pouch
- Current diagnosis or suspicion of primary sclerosing cholangitis
- Pregnancy or breastfeeding, or intention of becoming pregnant during the study
- Past or current evidence of definite low-grade or high-grade colonic dysplasia or
adenomas or neoplasia not completely removed
- History of malignancy within 5 years, with the exception of malignancies adequately
treated with resection for non-metastatic basal cell or squamous cell cancer or in
situ cervical cancer
- Evidence of infection with Clostridioides difficile (C. difficile; formerly known as
Clostridium difficile), cytomegalovirus (CMV), human immunodeficiency virus (HIV),
Hepatitis B (HBV), Hepatitis C (HCV)
- Has evidence of active tuberculosis (TB), latent TB not successfully treated (per
local guidance) or inadequately treated TB
- Has received protocol-specified prohibited medicines, including known exposure to
any type of anti-TL1A therapy