CLINICAL TRIAL / NCT05746559

Inclusion Criteria: - Participant weighs ≥ 30 kg - Planned non-emergent sternotomy with CPB procedure for the following surgeries: - Multi-vessel CABG - Valve replacement or repair; ascending aorta surgery permitted if combined with aortic valve replacement/repair - Combined CABG and valve surgery; inclusion of single-vessel CABG when combined with valve replacement/repair is permitted - Known CKD for at least 90 days (CKD Stage 3A, 3B, or 4) Exclusion Criteria: - Emergency or salvage cardiac surgery is expected at screening or randomization, as assessed by the Investigator. - Single-vessel CABG without valve surgery is planned. - Off-pump surgery is planned (eg, surgery without CPB). - Recipient of a solid organ or bone marrow transplantation. - Cardiogenic shock, hemodynamic instability, use of intra-aortic balloon pump, extracorporeal membrane oxygenation, or left ventricular assist device within 72 hours of randomization. - Active systemic bacterial, viral, or fungal infection within 14 days prior to randomization. - History of unexplained, recurrent infection. - Any use of KRT or presence of AKI within 30 days of randomization - Use of any complement inhibitors, or plasmapheresis or plasma exchange within the year prior to Screening, or planned use during the course of the study. - Participant is not willing to be vaccinated against N meningitidis or is unwilling to receive prophylactic treatment with appropriate antibiotics, if needed - History of or unresolved N meningitidis infection.