Substantial evidence indicates that obstructive sleep apnea (OSA) is associated with
impaired glucose metabolism, however, metabolic mechanisms underlying this association
remain unclear. This mechanistic study will determine systemic and cellular metabolic
pathways that contribute to impaired glucose metabolism in obstructive sleep apnea (OSA).
Understanding of how obstructive sleep apnea (OSA) affects glucose metabolism may help
identify novel targets for risk prediction and/or treatment of metabolic impairments
beyond continuous positive airway pressure (CPAP). Obstructive sleep apnea (OSA) patients
with prediabetes will be studied under three in-laboratory conditions in a randomized
cross-over design: untreated condition (obstructive sleep apnea), treated condition
(continuous positive airway pressure), untreated but pharmacologically suppressed
lipolysis condition (Niacin). The investigator will perform whole body and cellular
assessments under each study condition.
