CLINICAL TRIAL / NCT04262206
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
- Interventional
- Recruiting
- NCT04262206
Contact Information
PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
PREVENTABLE will randomly assign atorvastatin 40 mg daily or matching placebo daily to 20,000
community-dwelling adults 75 years of age or older without clinically evident cardiovascular
disease, significant disability, or dementia, and follow them for up to 5 years (estimated
median of 3.8 years). The study will enroll participants from approximately 100 US sites.
Community engagement efforts will leverage community groups and practices as collaborators
for recruitment. We plan to partner with participants, caregivers, and clinicians in all
aspects of the study. The enrolling sites are non-VA and VA sites. Each site will apply a
study-specific cohort identification algorithm to their electronic health record to create a
list of eligible participants based on study inclusion and exclusion criteria. The cohort
identification will exclude individuals with clinically evident cardiovascular disease,
significant disability, or dementia and other exclusions obtainable from data queries to
define a potential cohort. Sites will screen potential participants to confirm eligibility
and consent and randomize those interested in joining the study. Specifically related to
dementia, the qualifying exclusion is a clinical diagnosis in the chart or clinician's
assessment that dementia may be present. Sites will enter contact information, mailing
address for study drug, demographic information, height, weight, statin history (if any),
Social Security Number, and aspects of the medical history not obtainable from EHR. In
addition, a Short Physical Performance Battery (SPPB) and Activities of Daily Living (ADL)
screen will be site-performed at baseline. SPPB will provide an objective assessment of
function for understanding frailty and physical function of the enrolled population. Baseline
lipid panel (core lab) and biospecimen samples will be obtained using the same blood draw for
20cc of blood. Blinded lipid testing will be performed at baseline on all participants
(n=20,000) and repeated at 3 months in a random subset (n=2,000). Lipid panels will be sent
to the PREVENTABLE Core Lab to maintain study blind. Future testing of lipid panels during
routine clinical care will be actively discouraged, but other laboratory testing as indicated
by clinical care is permitted.Sites will have the option for telehealth enrollment. Baseline
SPPB and Biorepository Labs are not required, but encouraged.
As part of the study operations, with the rationale of providing patient centricity, ease of
participation, and access for vulnerable and at risk participants, follow up will be
performed by a combination of central and distributed research teams. This includes a call
center as well as a nationwide system of decentralized research staff trained on the protocol
able to meet the patient in their home or other desired location. The baseline and annual
assessments performed centrally will include a phone screen for cognitive function (TICS-M)
and physical function (Patient-reported Outcome Measurement Information System-Physical
Function [PROMIS-PF]). After year 1, If baseline calls indicated by crossing pre-specified
cutpoints, in-person assessments will be completed by trained and certified research staff at
a mutually agreed upon time and a standardized interview of a knowledgeable informant.
Cardiovascular event ascertainment will be via a systematic approach to data curation from
the EHR, Medicare, and National Death Index. For convenience and compliance, the study
pharmacy will mail a supply of study drug, sufficient for 90 days, directly to participants.
This will start immediately after randomization and continue as long as the participant is on
study drug.
Gender
All
Age Group
75 Years and up
Accepting Healthy Volunteers
Accepts Healthy Volunteers
Inclusion Criteria:
- Community-dwelling adults
- Age ≥75 years
- English or Spanish as primary language
Exclusion Criteria:
- Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI),
prior stroke, prior revascularization procedure, or a secondary prevention indication
for a statin (clinician determined)
- Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note:
History of heart failure in the absence of recent hospitalization or clinically
evident cardiovascular disease is not an exclusion)
- Dementia (clinically evident or previously diagnosed)
- Dependence in any Katz Basic Activities of Daily Living [ADL] (with the exception of
urinary or bowel continence)
- Severe hearing impairment (preventing phone follow up)
- Unable to talk (preventing phone follow up)
- Severe visual impairment (preventing cognitive testing)
- Statin use in the past year or for longer than 5 years previously (participant
reported)
- Ineligible to take atorvastatin 40 mg (clinician determined)
- Documented intolerance to statins
- Active Liver Disease
- Long-term use of daily colchicine, verapamil at any dose, or diltiazem at a dose
>240mg/day.