9 Clinical Trials

Allogenic Islet Cell Transplantation

The purpose of this study is to determine the safety of transplanting human islet cells for controlling hyperglycemia in brittle and/or complex patients with type 1 diabetes. In addition, initial observations will be made with regards to the effectiveness of...

Interventional / Recruiting / NCT00160732

Colesevelam for Children With Type 2 Diabetes

This study will see if the study drug will be a good treatment for type 2 diabetes in children 10 to 17 years old. The groups will be low-dose and high-dose. The children will have a 2 in 5 chance...

Interventional / Recruiting / NCT01258075

A Safety, Tolerability and Efficacy Study of Sernova's Cell Pouch™ for Clinical Islet Transplantation

The Cell Pouch™ is a novel implantable device, that is transplanted with therapeutic cells such as insulin producing islets. This combination product is designed for the treatment of Type 1 Diabetes Mellitus (T1DM) with hypoglycemia unawareness and a history of...

Interventional / Recruiting / NCT03513939

Multicenter ESG Trial (MERIT Trial)

Endoscopic Sleeve Gastroplasty (ESG) is an endoscopic minimally invasive weight loss procedure where a commercially available, FDA approved, full-thickness endoscopic suturing device (Overstitch; Apollo Endosurgery, Austin, TX) is used to reduce the stomach volume by...

Interventional / Recruiting / NCT03406975

A Study of Autologous Neo-Kidney Augment™ (NKA) in Patients With Diabetic Chronic Kidney Disease

Therapeutic intervention with NKA is intended to delay the need for renal replacement therapy (dialysis or transplant) which, based on the current standard of care, is inevitable for patients with end stage CKD. The purpose of the present study is...

Interventional / Recruiting / NCT03270956

Islet Transplantation in Type 1 Diabetic Kidney Allograft

The purpose of this study is to learn about the safety of islet transplantation when performed after kidney transplantation, which may provide more normal control of blood sugar without the need for insulin shots. Islets are special clusters of cells...

Interventional / Not Recruiting / NCT01241864

Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"

The study will determine whether the anti-CD3 monoclonal antibody, teplizumab, can help to prevent or delay the onset of type 1 diabetes (T1D) in relatives determined to be at very high risk for developing the disease. Teplizumab has been studied...

Interventional / Not Recruiting / NCT01030861

A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes

The primary purpose of this study is to determine if golimumab can preserve beta-cell function in children and young adults with newly diagnosed Type 1 Diabetes (T1D).

Interventional / Not Recruiting / NCT02846545

ATG-GCSF in New Onset Type 1 Diabetes

This is a three-arm, 1:1:1 randomized, placebo controlled, double- blinded trial in which at least 28 subjects will receive active Anti-Thymocyte Globulin and Granulocyte colony-stimulating factor (ATG-GCSF), at least 28 subjects will receive ATG alone and at...

Interventional / Not Recruiting / NCT02215200

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