Gender
All
Age Group
18 Years and up
Accepting Healthy Volunteers
No
Inclusion Criteria:
- Persons receiving ongoing oncology care at the University of Chicago Medical Center
for whom near-future pain opioid pain medication therapy is anticipated
- Subjects must be at least 18 years of age.
Exclusion Criteria:
- Subjects taking an opioid at the time of enrollment, or within the past 30 days
- Subjects who are currently undergoing palliative radiation
- Subjects who have undergone, or are being actively considered for, bone marrow,
liver or kidney transplantation.
- Subjects with a history of or active blood cancer (e.g., leukemia).
- Chronic kidney disease, as defined by Glomerular filtration rate (GFR) <
30/mL/min/1.73m2, due to the risk of decreased drug excretion.
- Liver dysfunction, as defined by the following laboratory values, due to the risk of
decreased drug metabolism: Total bilirubin greater than or equal to1.5 mg/dL,
Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) greater than or
equal to 2.5 X upper limit of normal*. (*Aspartate Aminotransferase (AST) and
Alanine Aminotransferase (ALT) \ greater than or equal to 5 X upper limit of normal
if hepatic metastases are present).
- Inability to understand and give informed consent to participate in the opinion of
the investigator
- Subjects who are known to be pregnant at the time of enrollment
- Subjects who are enrolled in other Pharmacogenomic (PGx) studies