CLINICAL TRIAL / NCT05254834

Key Inclusion Criteria: - Age at least 30 years - Able and willing to provide blood samples per protocol - Able to comprehend and willing to sign and date the informed consent documents - Participants must meet one of the following: - Diagnosed with a single primary cancer that has not yet been treated - No evidence or treatment of any cancer for at least 5 years prior to enrollment Key Exclusion Criteria: - A medical condition which, in the opinion of the investigator, should preclude enrollment in the study - Known to be pregnant - Any therapy for cancer, including surgery, chemotherapy, immunotherapy, and/or radiation therapy in the 5 years preceding enrollment - Participated or currently participating in a clinical research study in which an experimental medication has been administered in the last 30 days - Participated in or currently participating in another Freenome clinical study - For the control cohort: Any previous cancer diagnosis in the 5 years preceding enrollment, or recurrence of the same primary cancer within any timeframe; or concurrent diagnosis of multiple primary cancers within any timeframe - For the cancer cohorts: Any previous cancer diagnosis in the 5 years preceding enrollment, apart from the current cancer diagnosis; OR recurrence of the same primary cancer within any timeframe; OR concurrent diagnosis of multiple primary cancers within any timeframe