CLINICAL TRIAL / NCT03595683
Pembrolizumab and EDP1503 in Advanced Melanoma
- Interventional
- Active
- NCT03595683
Contact Information
Phase II Dual-Cohort Study Evaluating the Effects of Pembrolizumab in the Presence of Gut Microbiota Modulation With EDP1503 in Advanced Melanoma Naïve or Refractory to Anti-PD1 Antibody
This study is being done to determine if orally administered EDP1503 will enhance the response to standard immunotherapy treatment (pembrolizumab) in participants with advanced melanoma. The study will involve initial administration of EDP1503 for a run-in period (2 weeks) followed by administration of both EDP1503 (twice daily) and pembrolizumab (every 3 weeks). Mandatory biopsies are required before starting study treatment and after 2 weeks of EDP1503 dosing.
Gender
All
Age Group
18 Years and up
Accepting Healthy Volunteers
No
Inclusion Criteria:
- Advanced, unresectable or metastatic melanoma
- Be willing and able to provide written informed consent/assent for the trial.
- Aged 18 years or older on day of signing informed consent.
- Have measurable disease based on Response Evaluation Criteria In Solid Tumors
(RECIST) 1.1.
- Be naïve to exposure in the metastatic setting to PD1/L1 antibody for cohort 1 but
have had exposure to PD1/L1 (or PD1/L1 combination therapy) in cohort 2. Prior
exposure to CTLA4 antibody in the metastatic setting is not allowed for cohort 1
though exposure in the adjuvant setting is allowed for either cohort. To be eligible
for cohort 2, and considered refractory to PD1/L1, a patient must have had a
restaging exam showing progressive disease at least 90 days following initiation of
anti-PD1/L1 as prior therapy.
- Adjuvant therapy with BRAF-MEK, PD1 or CTLA4 based therapy is allowed. Prior
adjuvant BRAF-MEK therapy will fulfill treatment requirement in the metastatic
setting. Patients who experience progression of disease during adjuvant PD1
therapy or within 6 months of completing adjuvant PD1 therapy will be
considered refractory and thus eligible for cohort 1. Patients with progression
to active metastatic disease more than 6 months following completion of
adjuvant PD1 therapy will be eligible for cohort 1.
- Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
Performance Scale.
- Demonstrate adequate organ function as defined in Table 1, all screening labs should
be performed within 14 days of study initiation.
- Adequate Organ Function Laboratory Values
- Absolute neutrophil count (ANC) ≥1,500 /mcL
- Platelets ≥100,000 / mcL
- Hemoglobin ≥9 g/dL or ≥5.6 mmol/L without transfusion or EPO dependency (within
7 days of assessment)
- Serum creatinine OR Measured or calculated creatinine clearance (GFR can also
be used in place of creatinine or CrCl) ≤1.5 X upper limit of normal (ULN) OR
≥60 mL/min for subject with creatinine levels > 1.5 X institutional ULN
- Serum total bilirubin ≤ 1.5 X ULN OR Direct bilirubin ≤ ULN for subjects with
total bilirubin levels > 1.5 ULN
- aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 X ULN
OR ≤ 5 X ULN for subjects with liver metastases
- Albumin >2.5 mg/dL
- Female subject of childbearing potential should have a negative urine or serum
pregnancy within 72 hours prior to receiving the first dose of study medication. If
the urine test is positive or cannot be confirmed as negative, a serum pregnancy
test will be required.
- Female subjects of childbearing potential must be willing to use an adequate method
of contraception for the course of the study through 120 days after the last dose of
study medication. [Note: Abstinence is acceptable if this is the usual lifestyle and
preferred contraception for the subject.]
- Male subjects of childbearing potential must agree to use an adequate method of
contraception starting with the first dose of study therapy through 120 days after
the last dose of study therapy. [Note: Abstinence is acceptable if this is the usual
lifestyle and preferred contraception for the subject.]
Exclusion Criteria:
- For cohort 2: Has BRAF mutant disease but has not yet received treatment with
RAF/MEK inhibitors. This criteria can be met via adjuvant treatment with BRAF-MEK
inhibitors
- Is currently participating and receiving study therapy or has participated in a
study of an investigational agent and received study therapy or used an
investigational device within 2 weeks of the first dose.
- Is currently taking Bifidobacterium based probiotics or is taking pre/pro-biotics
regularly.
- Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any
other form of immunosuppressive therapy within 7 days prior to the first dose.
- Has a known history of active Bacillus Tuberculosis (TB)
- Hypersensitivity to pembrolizumab or any of its excipients.
- Has had a prior anti-cancer monoclonal antibody (mAb) within 3 weeks prior to study
Day 1 (excluding anti-PD1 antibodies such as pembrolizumab or nivolumab in cohort 2)
or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to
agents administered more than 4 weeks earlier.
- Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy
within 2 weeks prior to study Day 1 or who has not recovered (i.e., ≤ Grade 1 or at
baseline) from adverse events due to a previously administered agent.
- Note: Subjects with ≤ Grade 2 neuropathy are an exception to this criterion and
may qualify for the study.
- Note: If subject received major surgery, they must have recovered adequately
from the toxicity and/or complications from the intervention prior to starting
therapy.
- Has a known additional malignancy that is progressing or requires active treatment.
Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of
the skin that has undergone potentially curative therapy or in situ cervical cancer.
- Has known active central nervous system (CNS) metastases and/or carcinomatous
meningitis. Subjects with previously treated brain metastases may participate
provided they are stable (without evidence of progression by imaging for at least
four weeks prior to the first dose and any neurologic symptoms have returned to
baseline), have no evidence of new or enlarging brain metastases, and are not using
steroids for at least 7 days prior to start of study. This exception does not
include carcinomatous meningitis which is excluded regardless of clinical stability.
- Has active autoimmune disease that has required systemic treatment in the past 2
years (i.e. with use of disease modifying agents, corticosteroids or
immunosuppressive drugs). Replacement therapy (eg., thyroxine, insulin, or
physiologic corticosteroid replacement therapy for adrenal or pituitary
insufficiency, etc.) is not considered a form of systemic treatment.
- Has known history of, or any evidence of active, non-infectious pneumonitis.
- Has an active infection requiring antibiotic therapy or has received a course of
antibiotics within the previous 2 weeks of starting study treatment.
- Has a history or current evidence of any condition, therapy, or laboratory
abnormality that might confound the results of the trial, interfere with the
subject's participation for the full duration of the trial, or is not in the best
interest of the subject to participate, in the opinion of the treating investigator.
- Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
- Is pregnant or breastfeeding, or expecting to conceive or father children within the
projected duration of the trial, starting with the screening visit through 120 days
after the last dose of trial treatment.
- Has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies).
- Has known active Hepatitis B or Hepatitis C
- Has received a live vaccine within 30 days of planned start of study therapy. [Note:
Seasonal influenza vaccines for injection are generally inactivated flu vaccines and
are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live
attenuated vaccines, and are not allowed.]