Mechanisms of Prediabetic States in Sleep Apnea

  • Interventional
  • Recruiting
  • NCT04234217
Eligibility Details Visit

Mechanisms of Prediabetic States in Sleep Apnea

The purpose of this study is to better understand how sleep apnea contributes to the development of diabetes.

Substantial evidence indicates that obstructive sleep apnea (OSA) is associated with impaired glucose metabolism, however, metabolic mechanisms underlying this association remain unclear. This mechanistic study will determine systemic and cellular metabolic pathways that contribute to impaired glucose metabolism in obstructive sleep apnea (OSA). Understanding of how obstructive sleep apnea (OSA) affects glucose metabolism may help identify novel targets for risk prediction and/or treatment of metabolic impairments beyond continuous positive airway pressure (CPAP). Obstructive sleep apnea (OSA) patients with prediabetes will be studied under three in-laboratory conditions in a randomized cross-over design: untreated condition (obstructive sleep apnea), treated condition (continuous positive airway pressure), untreated but pharmacologically suppressed lipolysis condition (Niacin). The investigator will perform whole body and cellular assessments under each study condition.


Age Group
20 Years to 65 Years

Accepting Healthy Volunteers?

Inclusion Criteria:

         - Overweight or obese

         - Prediabetic

         - Sleep apnea

        Exclusion Criteria:

         - Diabetic

         - Severe hypertension

         - Taking medications that can confound assessments

         - Any history of known bleeding disorders

         - Any underlying disease likely to limit life span or increase risk of intervention

         - Currently pregnant, trying to get pregnant or nursing

At a Glance

National Government IDNCT04234217


Lead SponsorUniversity of Chicago

Lead PhysicianEsra Tasali


20 Years to 65 Years