CLINICAL TRIAL / NCT05512754

Inclusion Criteria: - Male patients age between 18-80 years old with a screening PSA > 3 ng/ml being considered for additional diagnostic testing (e.g., MRI, biopsy) - Normal digital rectal examination. - No clinical symptoms concerning acute urinary tract infection (e.g. dysuria, malodorous urine, positive urine culture) Exclusion Criteria: - Active urinary tract infections or bacteriuria - Known prostate cancer - Urethral catheter within the last 6 weeks - History of hypersensitivity or allergy to ibuprofen or NSAIDs. - Known severe chronic kidney disease: eGFR < 30 mL/min/1.73 m2 - Known history of severe liver disease (elevated AST or ALT greater than 3 times upper limit of normal) - History of gastrointestinal bleeding or NSAIDs induced GI adverse events - Concomitant dual-antiplatelet use or anticoagulants - Concomitant anti-inflammatory or steroidal drugs - Known bleeding disorder(s) - Patients with a solitary kidney or history of a kidney transplant - Any other medical contraindication to NSAIDs