CLINICAL TRIAL / NCT02445222

CAR-T Long Term Follow Up (LTFU) Study

  • Interventional
  • Active
  • NCT02445222

Long Term Follow-Up of Patients Exposed to Lentiviral-Based CAR T-Cell Therapy

Per Health Authorities guidelines for gene therapy medicinal products that utilize integrating vectors (e.g. lentiviral vectors), long term safety and efficacy follow up of treated patients is required. The purpose of this study is to monitor all patients exposed to CAR-T therapied for 15 years following their last CAR-T (e.g. CTL019) infusion to assess the risk of delayed adverse events (AEs), monitor for replication competent lentivirus (RCL) and assess long-term efficacy, including vector persistence.