Gender
All
Age Group
21 Years to 40 Years
Accepting Healthy Volunteers
Accepts Healthy Volunteers
Inclusion Criteria:
- Age: 21-40 years
- Body mass index: 25.0 to 29.9 kg/m2
- Average habitual sleep duration of 6.5 hours or less per night (as confirmed by
actigraphy)
- stable sleep habits for the past 6 months
Exclusion Criteria:
- obstructive sleep apnea or history of any other sleep disorder
- night or rotating shift work (current or in the past 2 years)
- habitual daytime naps
- recent (< 4 week) travel across time zones
- extreme chronotypes
- any acute or chronic medical condition
- diabetes
- prior or current eating or psychiatric disorders
- claustrophobia
- irregular menstrual periods, menopause, pregnancy,
- alcohol abuse, excessive caffeine intake, smoking, illegal drug use
- subjects who are currently following a weight loss regimen or any other special diet
or exercise programs
- subjects who have received iv or oral contrast in the past 2 weeks
- use of any prescription medication that can affect sleep or metabolism with the
exception of antihypertensive and lipid lowering agents as follows. Subjects who are
taking anti-hypertensive medication and/or lipid-lowering agents will be included
only if they are well controlled and on a stable regimen (no change in medications
in the previous 3 months). However, beta-blockers and thiazide diuretics will not be
allowed, as these medications are known to affect insulin sensitivity. Women will be
required to not be on hormone replacement therapy.