What is Proteus Syndrome?

Proteus syndrome (PS) is a rare condition in which bones, skin and other tissues grow out of proportion — and often asymmetrically — to the rest of the body. The condition may affect the left and right sides of the body differently. In addition to growth issues, the syndrome may cause large blisters, lung disease, enlargement of one side of the brain, blood clots and vascular malformations.

Many individuals with Proteus syndrome have skin capillary malformations, patterns of prominent veins or enlarged veins called varicosities. Large and complex vascular malformations also are sometimes seen in patients with Proteus syndrome.

Diagnosis & Treatment

The diagnosis and treatment of Proteus syndrome often requires several types of pediatric experts. The vascular anomalies team at Comer Children's evaluates, treats and monitors the vascular malformations associated with the syndrome and works closely with other specialists involved in the patient's care.

Treatments for vascular malformations related to Proteus syndrome may include:

  • Surgical removal of the malformation
  • Laser therapy to shrink the affected blood vessels
  • Sclerotherapy: The injection of a solution directly in the vein, causing it to collapse and forcing the blood to reroute through healthier veins

Why Choose Us?

The vascular anomalies program at Comer Children's offers an integrated and comprehensive approach to the diagnosis, care and management of vascular malformations. Our multidisciplinary team of pediatric experts works together to educate families and to evaluate and treat children with all types of these vascular lesions.

Resources & Support for Patients with Vascular Anomalies

Patient Resources at Comer Children’s

Kids want to feel like kids, even when they're sick. Our Child Life therapists use play, art and other approaches to take some of the scare away from the hospital experience and to help kids feel as normal as possible, in spite of their disease. Located near Comer Children's, the Ronald McDonald House provides a home away from home for families while their child is hospitalized.

Patient Resources & Support Groups

These organizations and support groups may be helpful to families and patients by providing support, education and treatment information on vascular anomalies.