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One year after opening in 1927, the University of Chicago Medicine expanded into pediatrics and children's health care.
In 1928, the University of Chicago began construction on the Home for Destitute and Crippled Children and, in 1931, it became trustee for the Country Home for Convalescent Children.
In 1938, the Chicago Lying-in Hospital, created for maternity care, was merged with the children's facility to create a unified approach to women's and children's health care.
In 1967, the University of Chicago Medicine’s Wyler Children's Hospital opened its doors. The hospital name was later changed to the University of Chicago Children's Hospital.
The state-of-the-art University of Chicago Medicine Comer Children's Hospital opened in Winter 2005.