CLINICAL TRIAL / NCT05615220

Inclusion Criteria: - ≥ 6 years of age - ≥ 18 kg (~ 40 lbs.) - TD diagnosis and both motor and vocal tics that cause impairment with normal routines - Minimum score of 20 on the YGTSS-R Total Tic Score - May not be taking any medications used to treat motor or vocal tics for at least 14 days prior to Baseline. - Effective contraception during the study and 30 days after last study dose for sexually active subjects Exclusion Criteria: - Previous exposure to ecopipam - Certain mood or psychiatric disorders (i.e., dementia, bipolar disorder, schizophrenia, major depressive disorder) - Unstable unstable medical illness or clinically significant lab abnormalities - Risk of suicide - Pregnant or lactating women - Moderate to severe renal insufficiency - Hepatic insufficiency - Positive urine drug screen - Unstable doses for drugs to treat anxiety, depression, Attention Deficit Hyperactivity Disorder - Certain medications that would lead to drug interactions - Recent behavioral therapy