CLINICAL TRIAL / NCT04978428

Inclusion Criteria: - Men and women age 18-65 - Primary diagnosis of OCD, Hoarding Disorder, Skin Picking Disorder, Trichotillomania, or Tourette Syndrome - YBOCS score of at least 18 at baseline - Ability to understand and sign the consent form. Exclusion Criteria: - Unstable medical illness based on history or clinically significant abnormalities on baseline physical examination or labs - Current pregnancy or lactation, or inadequate contraception in women of childbearing potential - Subjects considered an immediate suicide risk based on the Columbia Suicide Severity Rating Scale (C-SSRS) - Past 12-month DSM-5 psychiatric disorder other than OCD - Illegal substance use based on urine toxicology screening - Initiation of psychological interventions within 3 months of screening - Use of any other psychotropic medication - Previous treatment with Epidiolex - Cognitive impairment that interferes with the capacity to understand and self-administer medication or provide written informed consent