This is a multicenter registry and biorepository conducted in the United States (US) and
Canada. The registry will enroll over 3500 individuals with SLE over the course of five
years into one of following four cohorts:
- New Onset: individuals with a new diagnosis of SLE
- Active Lupus Nephritis: individuals with a recent diagnosis of LN
- Extra-Renal Lupus Flare: individuals who have experienced a recent flare
- Prevalent Cases: individuals with lupus who do not meet the criteria for one of the
other cohorts
The registry data will include but is not limited to: patient demographics, medical
history, clinician-reported outcomes (ClinROs), patient-reported outcomes (PROs), social
history and determinants of health, and environmental exposures. Participants will also
be asked to allow access to their medical records.
Biological samples, including whole blood, urine, saliva, stool and tissue will be
collected throughout the study. These biospecimens will be used for a broad range of
analyses, including genetics, genomics, proteomics, biomarker discovery and microbiome
profiling.