Incretin Regulation of Insulin Secretion in Monogenic Diabetes
- Interventional
- Recruiting
- NCT01795144
Contact Information
Incretin Regulation of Insulin Secretion in Monogenic Diabetes
The purpose of this study is to explore the mechanisms of metabolic control in monogenic diabetes patients treated with sulfonylurea medications.
Monogenic diabetes patients and healthy matched controls will be admitted to the University
of Chicago Clinical Resource Center for a total of 4 nights. The following will take place on
separate days:
1. Oral Glucose Tolerance Test (OGTT): consume sugary drink and blood samples will be collected at multiple time points
2. Isoglycemic glucose infusion (IGI) test: glucose will be infused via a vein in the arm and and blood samples will be collected at multiple time points
3. OGTT during GLP-1 infusion
4. IGI during Exendin-9 infusion
1. Oral Glucose Tolerance Test (OGTT): consume sugary drink and blood samples will be collected at multiple time points
2. Isoglycemic glucose infusion (IGI) test: glucose will be infused via a vein in the arm and and blood samples will be collected at multiple time points
3. OGTT during GLP-1 infusion
4. IGI during Exendin-9 infusion
Gender
All
Age Group
18 Years to 89 Years
Accepting Healthy Volunteers?
Accepts Healthy Volunteers
Monogenic Diabetes Subjects:
Inclusion Criteria:
- Diagnosis of monogenic diabetes
- Previously participated in US Neonatal Diabetes Registry (IRB 15617B) or Genetics of diabetes mellitus (IRB 6858)
- Age: 18 years +
Exclusion Criteria:
- Pregnancy
- Acute medical illness or chronic conditions including: cardiac failure, renal insufficiency (estimated glomerular filtration rate <50 ml/min), hepatic insufficiency (known cirrhosis or hepatitis), chronic obstructive pulmonary disease, gastrointestinal disorders causing malabsorption, anemia (Hct < 36%), or uncontrolled hypertension
Healthy Controls:
Inclusion Criteria:
- Good general health
- Stable weight for 6 months
- Age: 18 years +
Exclusion Criteria:
- Pregnancy
- Acute medical illness or chronic conditions including: cardiac failure, renal insufficiency (estimated glomerular filtration rate <50 ml/min), hepatic insufficiency (known cirrhosis or hepatitis), chronic obstructive pulmonary disease, gastrointestinal disorders causing malabsorption, anemia (Hct < 36%), or uncontrolled hypertension
Inclusion Criteria:
- Diagnosis of monogenic diabetes
- Previously participated in US Neonatal Diabetes Registry (IRB 15617B) or Genetics of diabetes mellitus (IRB 6858)
- Age: 18 years +
Exclusion Criteria:
- Pregnancy
- Acute medical illness or chronic conditions including: cardiac failure, renal insufficiency (estimated glomerular filtration rate <50 ml/min), hepatic insufficiency (known cirrhosis or hepatitis), chronic obstructive pulmonary disease, gastrointestinal disorders causing malabsorption, anemia (Hct < 36%), or uncontrolled hypertension
Healthy Controls:
Inclusion Criteria:
- Good general health
- Stable weight for 6 months
- Age: 18 years +
Exclusion Criteria:
- Pregnancy
- Acute medical illness or chronic conditions including: cardiac failure, renal insufficiency (estimated glomerular filtration rate <50 ml/min), hepatic insufficiency (known cirrhosis or hepatitis), chronic obstructive pulmonary disease, gastrointestinal disorders causing malabsorption, anemia (Hct < 36%), or uncontrolled hypertension