18 Years to 80 Years
Accepting Healthy Volunteers?
1. Diagnosis of CCM of any genotype supported by relevant imaging studies.
2. Symptomatic CCM bleeding event within 1 year prior to enrollment.
3. Must be willing/able to travel to the study site for all study visits (baseline, 12
months, and 24 months) over the course of the study period.
1. Pre-menopausal women who are breastfeeding, pregnant or likely to get pregnant during
the study period.
2. Previous cranial irradiation or surgical/radiosurgical treatment of CCM lesion.
3. Failure to pass MRI safety screening (claustrophobia, metal implant . . . etc)
4. Known allergy or intolerance to gadolinium.
5. Severely impaired renal function (eGFR < 60ml/min), active renal disease or status
6. Statin therapy, for any indication, within 12 months preceding enrollment.
7. Indication to use statin medication for current approved indication, unrelated to CCM
8. Known allergy or intolerance to statins
9. Liver dysfunction or active liver disease (including chronic viral hepatitis) defined
as baseline serum transaminases levels twice the upper range of normal.
10. Previous diagnosis of skeletal muscle disorders of any cause (myopathy), or baseline
creatine kinase level five times the upper range of normal.
11. Currently treated with or likely to need treatment with one or more of prohibited
medications listed in the protocol.
12. Active drug or alcohol use or dependence that, in the opinion of the site
investigator, would interfere with adherence to study requirements.
13. Serious illness (requiring systemic treatment and/or hospitalization) until subject
either completes therapy or is clinically stable on therapy, in the opinion of the
site investigator, for at least 30 days prior to study entry.
14. Any other condition that the investigator believes would pose a significant hazard to
the subject if the investigational therapy were initiated, including conditions
resulting in or precipitating myopathy (e.g. HIV, uncontrolled hypothyroidism).
15. In the investigator's opinion, the patient is unstable, and would benefit from a
specific intervention rather than treatment with atorvastatin.
16. Inability or unwillingness of subject or legal guardian/representative to give written
17. No documentation of valid healthcare insurance.
18. No medical record confirmation of primary care physician.